 |
 |
 |
 |
 |
>
> >
> > We have just seen a case that is suspected of being AML but is
> > positive for CD13 only. It is negative for all other markers
> > including CD45. This patient has presented with bilateral renal
> > masses and a deep iliac mass. A random bone marrow showed a diffuse
> > infiltrate of blast cells believed to be myeloid but only CD13
> > positive. Has anyone else seen any AMLs that are only positive for
> > CD13?
> >
> > Thanks for the help.
> >
> > Haywood Pyle
> > pyle@kfshrc.edu.sa
> >
> >Hi!
> I have not seen such a case in a rather large material
> (approx.300 cases studied) !
> Did you check cytoplasmic staining for CD22, CD3, myeloperoxidase? Is CD117
> and CD56 also negative?
> CD13 reacts with aminopeptidase-N (ref. among others Favaloro et al,
> Leukocyte typing V,p.1788, Oxford University Press 1995), so it is not
> impossible that non-hematopoietic tumors may react. Is it possible to
> perform cytochemistry (eg chloracetate esterase) on cytologic material?
> Would be grateful to know the facit when you have it!
> Best wishes
> Anna Porwit-MacDonadl
> Haematopathology Lab., Department of Pathology,
> Karolinska Hopital, Stockholm
> >
>
> I agree with Anna and her questions. I have not seen a case like this
in about 1,000 cases of AML studied.
Regards, Elisabeth Paietta
|
|
|
|
|
|
CD-ROM Vol 3 was produced by Monica M. Shively and other staff at the
Purdue University Cytometry Laboratories and distributed free of charge
as an educational service to the cytometry community.
If you have any comments please direct them to
Dr. J. Paul Robinson, Professor & Director,
PUCL, Purdue University, West Lafayette, IN 47907.
Phone: (765)-494-0757;
FAX(765) 494-0517;
Web