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I have read some of the responses to your question. I certainly agree
with Maryalice and Dan from City of Hope. We have flowed many follicular
lymphomas (lymph nodes) and their corresponding PB and/or BM samples. By
no means are they all CD10 positive. This is based on routine histology
as a gold standard, but includes many cases with classic t(14;18) by
cytogenetics ie; good cases. I would not make this specific diagnosis on
the phenotype you described, as it could fit with several different
small cell B-lineage LPDs. Most of the comments Maryalice made are very
true. The compilation of all the data may allow a diagnosis in your
case, but I would not recommend a specific morphologic call based on a
non-specific immunophenotype. Interestingly, even the cases of FL
without a t(14;18) by cytogenetics (non t(14;18) FL cases) are CD10
positive at the same frequency as " garden-variety " FL.
Randy Gascoyne
Hematopathologist
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CD-ROM Vol 3 was produced by Monica M. Shively and other staff at the
Purdue University Cytometry Laboratories and distributed free of charge
as an educational service to the cytometry community.
If you have any comments please direct them to
Dr. J. Paul Robinson, Professor & Director,
PUCL, Purdue University, West Lafayette, IN 47907.
Phone: (765)-494-0757;
FAX(765) 494-0517;
Web