DiGeorge Syndrome B cells
William Ainsley Baughman (wab@gwis2.circ.gwu.edu)
Fri, 16 Jun 1995 15:31:39 -0400 (EDT)
We are monitoring lymphocyte subsets on a partial DiGeorge patient. From
day 13 to 3 months age, the T cells have slowly increased. However, B
cells have declined from 25% of lymphs (228 B cells / uL) to 9% (99 B
cells / uL).
The patient received large amounts of gamma globulin.
The question is: can neonatal administration of gammma-g suppress B cell
development? Information from clinical or animal models would be helpful.
Charles F. Repetti