- Not strictly a flow-related question!
I have a two part question regarding bone marrow/peripheral blood recovery from
cytotoxic drugs like 5-Fluoruracil, cyclophosphamide, and doxorubicin.
1. While these drugs kill rapidly dividing cells, is there a "preference" for
certain cells types (e.g. pre-B cells, grans, monos etc.) Also, has anyone else
tracked the recovery rates of various cell types following administration of
these drugs? (human or murine) This is certainly related to engines of
hematapoiesis and cell lifespans.
2. For the clinical people: What doses of these drugs are of clinical
relevance- that is, what doses are effective for tumor-killing, without killing
the patient? I am trying to interpret our mouse models of recovery.
Thanks in advance for any input,
Jeff
Please reply to me directly at:
jeff_carrell@hgsi.com