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I have had some experience with this entity and we are writing up the Mayo
cases seen so far. Unfortunately, its an aggressive disease. There are no
known protocols - its really too rare for a protocol. I'd recommend: 1. An
adriamycin containing regimen such as CHOP, CDE infusional (actually ECOG does
have this open as a protocol and the patient could probably enter it --its for
aggressive NHL not specifically gamma-delta), ProMACECytaBOM
2. If responsive, I'd check the blood and marrow and transplant if clean. 3.
If not a transplant candidate and does not get a CR with regimen in #1 then
I'd try a platinum regimen OR 2-deoxycoformycin- Pentostatin (good for T-cell
processes and commercially available and usually outpatient and
well-tolerated.
Sincerely,
Tom Witzig (witzig.thomas@mayo.edu)
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CD-ROM Vol 3 was produced by Monica M. Shively and other staff at the
Purdue University Cytometry Laboratories and distributed free of charge
as an educational service to the cytometry community.
If you have any comments please direct them to
Dr. J. Paul Robinson, Professor & Director,
PUCL, Purdue University, West Lafayette, IN 47907.
Phone: (765)-494-0757;
FAX(765) 494-0517;
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