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MRK-16 is available from Kamiya Biomedical Company, Thousand Oaks,
CA. Fax (818) 706-8763. Note that the MRK-16 epitope can be masked in
some clinical samples; we therefore use neuraminidase pretreatment.
We also found that the level of antigen expression appears to
underestimate Pgp function in AML patient samples (Xie et al., Leukemia
1995;9:1882-87). We think this may be because some are expressing
additional members of the ABC gene superfamilly that are capable of
transporting cytotoxic drugs but antigenically distinct from classical Pgp.
David Hedley
Princess Margaret Hospital/Ontario Cancer Institute
Toronto
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CD-ROM Vol 3 was produced by Monica M. Shively and other staff at the
Purdue University Cytometry Laboratories and distributed free of charge
as an educational service to the cytometry community.
If you have any comments please direct them to
Dr. J. Paul Robinson, Professor & Director,
PUCL, Purdue University, West Lafayette, IN 47907.
Phone: (765)-494-0757;
FAX(765) 494-0517;
Web
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CD-ROM Vol 3 was produced by Monica M. Shively and other staff at the
Purdue University Cytometry Laboratories and distributed free of charge
as an educational service to the cytometry community.
If you have any comments please direct them to
Dr. J. Paul Robinson, Professor & Director,
PUCL, Purdue University, West Lafayette, IN 47907.
Phone: (765)-494-0757;
FAX(765) 494-0517;
Web