Evidence for Pathophysiologic Relevanceof Immature Reticulocyte Fraction (IRF)

• Erythropoietin therapeutic effect: IRF 1- 3 days

  • CD71 vs TO studies
  • BJH study, Major et al.

• Animal models

  • in vivo biotinylation studies
  • CD71 vs. TO studies

• BMT recovery

  • IRF earliest parameter of engraftment
  • various methods with demonstrated efficacy

Previous slide

Next slide

Back to first slide

View graphic version